Coming soon – my video replay at the SCDROCKS 2023 Conference in Bellevue, Washington

In the meantime, many of you asked for a list of scientific references that I presented during my talk.

Scientific References

Abdelbary, Mohamed M. H., Maximilian Hatting, Alexandra Bott, Andrea Dahlhausen, Doris Keller, Christian Trautwein, and Georg Conrads. “The Oral-Gut Axis: Salivary and Fecal Microbiome Dysbiosis in Patients with Inflammatory Bowel Disease.” Frontiers in Cellular and Infection Microbiology 12 (2022): 1010853. https://doi.org/10.3389/fcimb.2022.1010853.

AlShahrani, Ibrahim, Jagadish Hosmani, Abdulaziz AlShahrani, Rafi Ahmad Togoo, Sadatullah Syed, Syed M. Yassin, Harish C. Chandramoorthy, and Anantharam Devaraj. “High Altitude as a Possible Factor for Dysbiosis of Salivary Microbiome in Orthodontic Patients.” Archives of Oral Biology 119 (November 1, 2020): 104917. https://doi.org/10.1016/j.archoralbio.2020.104917.

Atarashi, Koji, Wataru Suda, Chengwei Luo, Takaaki Kawaguchi, Iori Motoo, Seiko Narushima, Yuya Kiguchi, et al. “Ectopic Colonization of Oral Bacteria in the Intestine Drives TH1 Cell Induction and Inflammation.” Science 358, no. 6361 (October 20, 2017): 359–65. https://doi.org/10.1126/science.aan4526.

Banez, Melissa J., Matthew I. Geluz, Anjali Chandra, Tesnim Hamdan, Olivia S. Biswas, Nathan S. Bryan, and Ernst R. Von Schwarz. “A Systemic Review on the Antioxidant and Anti-Inflammatory Effects of Resveratrol, Curcumin, and Dietary Nitric Oxide Supplementation on Human Cardiovascular Health.” Nutrition Research 78 (June 1, 2020): 11–26. https://doi.org/10.1016/j.nutres.2020.03.002.

Borgnakke, Wenche S., Robert J. Genco, Paul I. Eke, and George W. Taylor. “Oral Health and Diabetes.” In Diabetes in America, edited by Catherine C. Cowie, Sarah Stark Casagrande, Andy Menke, Michelle A. Cissell, Mark S. Eberhardt, James B. Meigs, Edward W. Gregg, et al., 3rd ed. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases (US), 2018. http://www.ncbi.nlm.nih.gov/books/NBK567975/.

Brito, Fernanda, Fabiana Cervo de Barros, Cyrla Zaltman, Ana Teresa Pugas Carvalho, Antonio Jose de Vasconcellos Carneiro, Ricardo Guimarães Fischer, Anders Gustafsson, and Carlos Marcelo de Silva Figueredo. “Prevalence of Periodontitis and DMFT Index in Patients with Crohn’s Disease and Ulcerative Colitis.” Journal of Clinical Periodontology 35, no. 6 (June 2008): 555–60. https://doi.org/10.1111/j.1600-051X.2008.01231.x.

Bryan, Nathan S. “Nitric Oxide Deficiency Is a Primary Driver of Hypertension.” Biochemical Pharmacology 206 (December 1, 2022): 115325. https://doi.org/10.1016/j.bcp.2022.115325.

Bryan, Nathan S. “Nitric Oxide Enhancement Strategies.” Future Science OA 1, no. 1 (August 2015). https://doi.org/10.4155/fso.15.48.

Bryan, Nathan S., Mia C. Burleigh, and Chris Easton. “The Oral Microbiome, Nitric Oxide and Exercise Performance.” Nitric Oxide 125–126 (August 1, 2022): 23–30. https://doi.org/10.1016/j.niox.2022.05.004.

Bryan, Nathan S., Gena Tribble, and Nikola Angelov. “Oral Microbiome and Nitric Oxide: The Missing Link in the Management of Blood Pressure.” Current Hypertension Reports 19, no. 4 (March 28, 2017): 33. https://doi.org/10.1007/s11906-017-0725-2.

Cameron, Simon J. S., Sharon A. Huws, Matthew J. Hegarty, Daniel P. M. Smith, and Luis A. J. Mur. “The Human Salivary Microbiome Exhibits Temporal Stability in Bacterial Diversity.” FEMS Microbiology Ecology 91, no. 9 (September 1, 2015): fiv091. https://doi.org/10.1093/femsec/fiv091.

Contaldo, Maria, Alberta Lucchese, Carlo Lajolo, Cosimo Rupe, Dario Di Stasio, Antonio Romano, Massimo Petruzzi, and Rosario Serpico. “The Oral Microbiota Changes in Orthodontic Patients and Effects on Oral Health: An Overview.” Journal of Clinical Medicine 10, no. 4 (February 16, 2021): 780. https://doi.org/10.3390/jcm10040780.

Cutler, C., M. Kiernan, J. R. Willis, L. Gallardo-Alfaro, P. Casas-Agustench, D. White, M. Hickson, T. Gabaldon, and R. Bescos. “Post-Exercise Hypotension and Skeletal Muscle Oxygenation Is Regulated by Nitrate-Reducing Activity of Oral Bacteria.” Free Radical Biology and Medicine 143 (November 1, 2019): 252–59. https://doi.org/10.1016/j.freeradbiomed.2019.07.035.

Donaldson, Gregory P., S. Melanie Lee, and Sarkis K. Mazmanian. “Gut Biogeography of the Bacterial Microbiota.” Nature Reviews Microbiology 14, no. 1 (January 2016): 20–32. https://doi.org/10.1038/nrmicro3552.

Elmaghrawy, Khalid, Séamus Hussey, and Gary P. Moran. “The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers?” Frontiers in Pediatrics 8 (2020): 620254. https://doi.org/10.3389/fped.2020.620254.

Elzayat, Hala, Ghaidaa Mesto, and Farah Al-Marzooq. “Unraveling the Impact of Gut and Oral Microbiome on Gut Health in Inflammatory Bowel Diseases.” Nutrients 15, no. 15 (January 2023): 3377. https://doi.org/10.3390/nu15153377.

Gopalakrishnan, Umarevathi, Rajalakshmi Thakshina Murthy, A. Sumathi Felicita, Abdulrahman Alshehri, Wael Awadh, Abdullah Almalki, Thilla Sekar Vinothkumar, et al. “Sulfate-Reducing Bacteria in Patients Undergoing Fixed Orthodontic Treatment.” International Dental Journal 73, no. 2 (April 1, 2023): 274–79. https://doi.org/10.1016/j.identj.2022.07.007.

Huang, Xiaoyan, Xiangyu Huang, Yi Huang, Jiarong Zheng, Ye Lu, Zizhao Mai, Xinyuan Zhao, Li Cui, and Shaohong Huang. “The Oral Microbiome in Autoimmune Diseases: Friend or Foe?” Journal of Translational Medicine 21, no. 1 (March 22, 2023): 211. https://doi.org/10.1186/s12967-023-03995-x.

Hyde, Embriette R., Fernando Andrade, Zalman Vaksman, Kavitha Parthasarathy, Hong Jiang, Deepa K. Parthasarathy, Ashley C. Torregrossa, et al. “Metagenomic Analysis of Nitrate-Reducing Bacteria in the Oral Cavity: Implications for Nitric Oxide Homeostasis.” PloS One 9, no. 3 (2014): e88645. https://doi.org/10.1371/journal.pone.0088645.

Irwin, Sally V., Luz Maria Deardorff, Youping Deng, Peter Fisher, Michelle Gould, Junnie June, Rachael S. Kent, Yujia Qin, and Fracesca Yadao. “Sulfite Preservatives Effects on the Mouth Microbiome: Changes in Viability, Diversity and Composition of Microbiota.” PloS One 17, no. 4 (2022): e0265249. https://doi.org/10.1371/journal.pone.0265249.

Kapil, Vikas, Syed M. A. Haydar, Vanessa Pearl, Jon O. Lundberg, Eddie Weitzberg, and Amrita Ahluwalia. “Physiological Role for Nitrate-Reducing Oral Bacteria in Blood Pressure Control.” Free Radical Biology & Medicine 55 (February 2013): 93–100. https://doi.org/10.1016/j.freeradbiomed.2012.11.013.

Kitamoto, Sho, Hiroko Nagao-Kitamoto, Yizu Jiao, Merritt G. Gillilland, Atsushi Hayashi, Jin Imai, Kohei Sugihara, et al. “The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.” Cell 182, no. 2 (July 23, 2020): 447-462.e14. https://doi.org/10.1016/j.cell.2020.05.048.

“The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.” Cell 182, no. 2 (July 23, 2020): 447-462.e14. https://doi.org/10.1016/j.cell.2020.05.048.

“The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.” Cell 182, no. 2 (July 23, 2020): 447-462.e14. https://doi.org/10.1016/j.cell.2020.05.048.

Kobayashi, Ryoki, Yasuhiro Ogawa, Tomomi Hashizume-Takizawa, and Tomoko Kurita-Ochiai. “Oral Bacteria Affect the Gut Microbiome and Intestinal Immunity.” Pathogens and Disease 78, no. 3 (April 1, 2020): ftaa024. https://doi.org/10.1093/femspd/ftaa024.

Kort, Remco, Martien Caspers, Astrid van de Graaf, Wim van Egmond, Bart Keijser, and Guus Roeselers. “Shaping the Oral Microbiota through Intimate Kissing.” Microbiome 2 (2014): 41. https://doi.org/10.1186/2049-2618-2-41.

Lamont, Richard J., Hyun Koo, and George Hajishengallis. “The Oral Microbiota: Dynamic Communities and Host Interactions.” Nature Reviews Microbiology 16, no. 12 (December 2018): 745–59. https://doi.org/10.1038/s41579-018-0089-x.

“The Oral Microbiota: Dynamic Communities and Host Interactions.” Nature Reviews Microbiology 16, no. 12 (December 2018): 745–59. https://doi.org/10.1038/s41579-018-0089-x.

Marsh, P. D. “Are Dental Diseases Examples of Ecological Catastrophes?” Microbiology 149, no. 2 (February 1, 2003): 279–94. https://doi.org/10.1099/mic.0.26082-0.

Mason, Matthew R., Philip M. Preshaw, Haikady N. Nagaraja, Shareef M. Dabdoub, Anis Rahman, and Purnima S. Kumar. “The Subgingival Microbiome of Clinically Healthy Current and Never Smokers.” The ISME Journal 9, no. 1 (January 2015): 268–72. https://doi.org/10.1038/ismej.2014.114.

Molinero, Natalia, Diego Taladrid, Irene Zorraquín-Peña, Miguel de Celis, Ignacio Belda, Alex Mira, Begoña Bartolomé, and M. Victoria Moreno-Arribas. “Ulcerative Colitis Seems to Imply Oral Microbiome Dysbiosis.” Current Issues in Molecular Biology 44, no. 4 (March 30, 2022): 1513–27. https://doi.org/10.3390/cimb44040103.

Mukherjee, Chiranjit, Christina O. Moyer, Heidi M. Steinkamp, Shahr B. Hashmi, Clifford J. Beall, Xiaohan Guo, Ai Ni, Eugene J. Leys, and Ann L. Griffen. “Acquisition of Oral Microbiota Is Driven by Environment, Not Host Genetics.” Microbiome 9, no. 1 (February 23, 2021): 54. https://doi.org/10.1186/s40168-020-00986-8.

Qi, Ying, Hui-min Wu, Zhao Yang, Yi-fei Zhou, Lei Jin, Miao-fang Yang, and Fang-yu Wang. “New Insights into the Role of Oral Microbiota Dysbiosis in the Pathogenesis of Inflammatory Bowel Disease.” Digestive Diseases and Sciences 67, no. 1 (January 1, 2022): 42–55. https://doi.org/10.1007/s10620-021-06837-2.

Ray, Katrina. “The Oral–Gut Axis in IBD.” Nature Reviews Gastroenterology & Hepatology 17, no. 9 (September 2020): 532–532. https://doi.org/10.1038/s41575-020-0346-0.

Read, Emily, Michael A. Curtis, and Joana F. Neves. “The Role of Oral Bacteria in Inflammatory Bowel Disease.” Nature Reviews Gastroenterology & Hepatology 18, no. 10 (October 2021): 731–42. https://doi.org/10.1038/s41575-021-00488-4.

The Role of Oral Bacteria in Inflammatory Bowel Disease.” Nature Reviews Gastroenterology & Hepatology 18, no. 10 (October 2021): 731–42. https://doi.org/10.1038/s41575-021-00488-4.

Rojas-Tapias, Daniel F., Eric M. Brown, Emily R. Temple, Michelle A. Onyekaba, Ahmed M. T. Mohamed, Kellyanne Duncan, Melanie Schirmer, et al. “Inflammation-Associated Nitrate Facilitates Ectopic Colonization of Oral Bacterium Veillonella Parvula in the Intestine.” Nature Microbiology 7, no. 10 (October 2022): 1673–85. https://doi.org/10.1038/s41564-022-01224-7.

Rouzi, Maierdanjiang, Xiaoqi Zhang, Qingsong Jiang, Hu Long, Wenli Lai, and Xiaolong Li. “Impact of Clear Aligners on Oral Health and Oral Microbiome During Orthodontic Treatment.” International Dental Journal, April 25, 2023. https://doi.org/10.1016/j.identj.2023.03.012.

Said, Heba S., Wataru Suda, Shigeki Nakagome, Hiroshi Chinen, Kenshiro Oshima, Sangwan Kim, Ryosuke Kimura, et al. “Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association with Oral Immunological Biomarkers.” DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes 21, no. 1 (February 2014): 15–25. https://doi.org/10.1093/dnares/dst037.

Sanz-Orrio-Soler, Icíar, Santiago Arias de Luxán, and Chirag C. Sheth. “Oral Colonization by Candida Species in Orthodontic Patients before, during and after Treatment with Fixed Appliances: A Prospective Controlled Trial.” Journal of Clinical and Experimental Dentistry 12, no. 11 (November 2020): e1071–77. https://doi.org/10.4317/jced.57565.

Satari, Leila, Alba Guillén, Àngela Vidal-Verdú, and Manuel Porcar. “The Wasted Chewing Gum Bacteriome.” Scientific Reports 10, no. 1 (October 8, 2020): 16846. https://doi.org/10.1038/s41598-020-73913-4.

Segata, Nicola, Susan Kinder Haake, Peter Mannon, Katherine P. Lemon, Levi Waldron, Dirk Gevers, Curtis Huttenhower, and Jacques Izard. “Composition of the Adult Digestive Tract Bacterial Microbiome Based on Seven Mouth Surfaces, Tonsils, Throat and Stool Samples.” Genome Biology 13, no. 6 (June 14, 2012): R42. https://doi.org/10.1186/gb-2012-13-6-r42.

Seminario-Amez, M, J Lopez-Lopez, A Estrugo-Devesa, R Ayuso-Montero, and E Jane-Salas. “Probiotics and Oral Health: A Systematic Review.” Medicina Oral Patología Oral y Cirugia Bucal, 2017, 0–0. https://doi.org/10.4317/medoral.21494.

Shokeen, Bhumika, Edward Viloria, Emily Duong, Masooma Rizvi, Guiselle Murillo, Joseph Mullen, Baochen Shi, et al. “The Impact of Fixed Orthodontic Appliances and Clear Aligners on the Oral Microbiome and the Association with Clinical Parameters: A Longitudinal Comparative Study.” American Journal of Orthodontics and Dentofacial Orthopedics 161, no. 5 (May 1, 2022): e475–85. https://doi.org/10.1016/j.ajodo.2021.10.015.

Shukla, Chandresh, Rajkumar Maurya, Vinod Singh, and Manisha Tijare. “Evaluation of Role of Fixed Orthodontics in Changing Oral Ecological Flora of Opportunistic Microbes in Children and Adolescent.” Journal of Indian Society of Pedodontics and Preventive Dentistry 35, no. 1 (2017): 34. https://doi.org/10.4103/0970-4388.199226.

Somineni, Hari K, Jordan H Weitzner, Suresh Venkateswaran, Anne Dodd, Jarod Prince, Arjuna Karikaran, Cary G Sauer, et al. “Site- and Taxa-Specific Disease-Associated Oral Microbial Structures Distinguish Inflammatory Bowel Diseases.” Inflammatory Bowel Diseases 27, no. 12 (May 14, 2021): 1889–1900. https://doi.org/10.1093/ibd/izab082.

Sun, Fubo, Ayaz Ahmed, Lina Wang, Ming Dong, and Weidong Niu. “Comparison of Oral Microbiota in Orthodontic Patients and Healthy Individuals.” Microbial Pathogenesis 123 (October 1, 2018): 473–77. https://doi.org/10.1016/j.micpath.2018.08.011.

Takeshita, Toru, Shinya Kageyama, Michiko Furuta, Hidenori Tsuboi, Kenji Takeuchi, Yukie Shibata, Yoshihiro Shimazaki, et al. “Bacterial Diversity in Saliva and Oral Health-Related Conditions: The Hisayama Study.” Scientific Reports 6, no. 1 (February 24, 2016): 22164. https://doi.org/10.1038/srep22164.

Tribble, Gena D., Nikola Angelov, Robin Weltman, Bing-Yan Wang, Sridhar V. Eswaran, Isabel C. Gay, Kavitha Parthasarathy, et al. “Frequency of Tongue Cleaning Impacts the Human Tongue Microbiome Composition and Enterosalivary Circulation of Nitrate.” Frontiers in Cellular and Infection Microbiology 9 (2019): 39. https://doi.org/10.3389/fcimb.2019.00039.

Vanhatalo, Anni, Jamie R. Blackwell, Joanna E. L’Heureux, David W. Williams, Ann Smith, Mark van der Giezen, Paul G. Winyard, James Kelly, and Andrew M. Jones. “Nitrate-Responsive Oral Microbiome Modulates Nitric Oxide Homeostasis and Blood Pressure in Humans.” Free Radical Biology and Medicine 124 (August 20, 2018): 21–30. https://doi.org/10.1016/j.freeradbiomed.2018.05.078.

Vanhatalo, Anni, Joanna E. L’Heureux, James Kelly, Jamie R. Blackwell, Lee J. Wylie, Jonathan Fulford, Paul G. Winyard, David W. Williams, Mark van der Giezen, and Andrew M. Jones. “Network Analysis of Nitrate-Sensitive Oral Microbiome Reveals Interactions with Cognitive Function and Cardiovascular Health across Dietary Interventions.” Redox Biology 41 (May 1, 2021): 101933. https://doi.org/10.1016/j.redox.2021.101933.

Vila, Taissa, Alexandra M. Rizk, Ahmed S. Sultan, and Mary Ann Jabra-Rizk. “The Power of Saliva: Antimicrobial and Beyond.” PLOS Pathogens 15, no. 11 (November 14, 2019): e1008058. https://doi.org/10.1371/journal.ppat.1008058.

Wei, Fangqiao, Xiangyu Sun, Yufeng Gao, Haoyu Dou, Yang Liu, Lili Su, Haofei Luo, et al. “Is Oral Microbiome of Children Able to Maintain Resistance and Functional Stability in Response to Short-Term Interference of Ingesta?” Protein & Cell 12, no. 6 (June 1, 2021): 502–10. https://doi.org/10.1007/s13238-020-00774-y.

Wilbert, Steven A., Jessica L. Mark Welch, and Gary G. Borisy. “Spatial Ecology of the Human Tongue Dorsum Microbiome.” Cell Reports 30, no. 12 (March 24, 2020): 4003-4015.e3. https://doi.org/10.1016/j.celrep.2020.02.097.

Yin, Andrew Lukas, David Hachuel, John P. Pollak, Ellen J. Scherl, and Deborah Estrin. “Digital Health Apps in the Clinical Care of Inflammatory Bowel Disease: Scoping Review.” Journal of Medical Internet Research 21, no. 8 (August 19, 2019): e14630. https://doi.org/10.2196/14630.

Zhang, Tianyu, Masood Ur Rehman Kayani, Liwen Hong, Chen Zhang, Jie Zhong, Zhengting Wang, and Lei Chen. “Dynamics of the Salivary Microbiome During Different Phases of Crohn’s Disease.” Frontiers in Cellular and Infection Microbiology 10 (2020): 544704. https://doi.org/10.3389/fcimb.2020.544704.